人胎儿和成人皮肤及其创面愈合过程中转化生长因子-β的表达

The expression and significance of TGF－β on the normal and wound healing of the human fetal and adult skin

目的探讨人胎儿和成人皮肤及其创面愈合过程中转化因子－β (TGF－β )的表达。方法利用已建立的人胎儿无瘢痕愈合动物模型，获取相应标本，结合临床所取成人皮肤标本，采用免疫组化染色方法，观察 TGF－β的表达情况。结果正常人胎儿皮肤及其创面愈合过程中 TGF－β的表达极低，无明显差异（ P>0.05），而上述表达与正常成人皮肤及其创面的表达之间差异显著（ P< 0.01）。结论 TGF－β的低水平表达可能是胎儿皮肤无瘢痕愈合的重要原因之一。

Objective To discuss the expression of TGF－β on the normal and wound healing of the human fetal and adult skin Method Species－ specific immunohistochemistry for TGF－β in the normal and wound healing of the human fetal and adult skin was performed.To observe the expression of TGF－β .Result TGF－β staining was not showed in the dermis of the normal feta(P >0.05).The expression of TGF－β on the mormal and wound healing of fetal was significant from that on the noumal and wound healing of adult skin.Conclusion The low level expression of TGF－β on the normal and wound healing of the fetal skin may be the important cause of fetal scarless healing.