摘要
目的探讨人胎儿和成人皮肤及其创面愈合过程中转化因子-β (TGF-β )的表达。方法利用已建立的人胎儿无瘢痕愈合动物模型,获取相应标本,结合临床所取成人皮肤标本,采用免疫组化染色方法,观察 TGF-β的表达情况。结果正常人胎儿皮肤及其创面愈合过程中 TGF-β的表达极低,无明显差异( P>0.05),而上述表达与正常成人皮肤及其创面的表达之间差异显著( P< 0.01)。结论 TGF-β的低水平表达可能是胎儿皮肤无瘢痕愈合的重要原因之一。
Objective To discuss the expression of TGF-β on the normal and wound healing of the human fetal and adult skin Method Species- specific immunohistochemistry for TGF-β in the normal and wound healing of the human fetal and adult skin was performed.To observe the expression of TGF-β .Result TGF-β staining was not showed in the dermis of the normal feta(P >0.05).The expression of TGF-β on the mormal and wound healing of fetal was significant from that on the noumal and wound healing of adult skin.Conclusion The low level expression of TGF-β on the normal and wound healing of the fetal skin may be the important cause of fetal scarless healing.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
2001年第14期60-61,共2页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
国家自然科学基金资助项目( 30000174)