脑性瘫痪患儿钙、磷营养状况及评价指标的探讨

Exploration of nutritional status of Ca,P and assessment index in children with cerebral palsy

目的 调查脑性瘫痪(脑瘫)患儿钙、磷代谢平衡及测定有关评价指标，及相互关系。方法 40例脑瘫患儿和30例正常对照儿测量Ca、P代谢平衡指标及血清Ca、P、骨钙素(ALP)、BGP浓度和骨密度（BMD）。结果 脑瘫患儿Ca、P代谢为正平衡，但每日骨Ca沉积量明显低于对照组（P< 0.05）；重度脑瘫患儿净Ca、P沉积量显著低于对照组（P< 0.01，P< 0.05）；脑瘫患儿血Ca、P与对照组比较无区别（P >0.05），血清ALP、BGP显著高于正常对照组（P< 0.01）；各年龄段CP患儿骨密度明显低于对照组（P< 0.05）。结论 脑瘫患儿每日Ca、P沉积不足；骨密度减低、血ALP、BGP升高说明骨矿化不足，骨形成旺盛，骨重建活跃。

Objective To survey the metabolic balance of Ca,P and assessment index and explore the correlation between them in children with cerebral palsy. Method The measurement of the metabolism balance of Ca,P and the levels of the serum Ca,P,ALP,BGP and bone density in 40 children with CP and 30 normal children. Result The metabolism of Ca、P in children with CP was positive balance, but the deposition of bone Ca was more lower than that in controls(P< 0.05).The level of bone deposition in severe children with CP was more lower than that in controls(P< 0.01, P< 0.05);The serum Ca,P in children with CP and normal children was no difference, ( P >0.05);the serum ALP、BGP was more higher than that in control; Bone density in the different age children with CP was more lower than that in controls (P< 0.05).Conclusion The children with CP are lack of Ca,P deposition every day, the low bone density and high serum ALP, BGP indicate poor mineralization and energetic bone formation and active bone rebuild.