固邦加钙剂治疗绝经后骨质疏松症的疗效及安全性观察

Alendronate and calcium carbonate in treatment of postmenopausal osteoporosis

目的观察固邦(阿仑磷酸钠)治疗绝经后骨质疏松症的疗效及安全性。方法绝经后骨质疏松症妇女50例，随机分为固邦组30例，年龄(64±4)岁；对照组20例，年龄(63±5)岁。两组均应用碳酸钙，每晚口服1片；固邦组加阿仑磷酸钠10 mg，口服，1次/d，晨空腹服，疗程均6个月。每组用药前后检测腰椎、髋部骨密度(BMD)，血尿粪常规、肝肾功能、电解质、碱性磷酸酶(AKP)。结果用药后治疗组腰椎、髋部BMD明显增高，骨痛改善，各生化指标无异常变化，对照组各指标无明显改善。两组间具有显著差异。结论阿仑磷酸钠对防治绝经后骨质疏松症是安全、有效的。

Objective To evaluate the clinical effects of alendronate in the treatment of postmenopausal osteoporosis.Method Fifty women with postmenopausal osteoporosis were randomly divided into the alendronate group of 30 patients,age (64±4)year,and the control group of 20 patients，age (63±5)year.All patients of both groups took calcium carbonate one tablet per night while those of the alendronate group also took alendronate before breakfast with empty stomach ,10 mg ,po ,qd ,for 6 months.Before and after being treated,patients of both groups were checked with BMD of L 2－4 and femur bone,the samples(blood,urine,stool,AKP,and expressed prostatic secretion).Rseult BMD of L 2－4 of the alendronate group and femur bone increased,boneache improved. Biochemical levels in the treating group didn't change and those of the controls didn't improve.There was significant difference between two groups.Conclusion Alendronate is effective and safe for treatment of postmenopausal osteoporosis.