铁离子对乳酸环丙沙星注射液变色的影响

Effect of iron ion on changing color of the injection of Ciprofloxacinum lactate

乳酸环丙沙星注射液由于在生产过程中带入铁离子而使颜色变黄,这是铁离子与环丙沙星形成缔合物的关系,但铁离子对乳酸环丙沙星含量并无影响。当加入EDTA就能络合与环丙沙星缔合的铁离子而退色,EDTA对环丙沙星的含量亦无影响。

The color of the injection of Ciprofloxacinum lactate may be changed to be yellow because iron ion gets into the solution and forms chelate with Ciprofloxacinum. This study indicated that: 1) iron ion did not affect the content of Ciprofloxacinum lactate in the injection; (2) yellow color might disappear when EDTA was added; 3) the addition of EDTA has no any effect on the content of Ciprofloxacinum in the injection.