摘要
生物芯片技术是基于生物大分子间相互作用的大规模并行分析方法 ,使得生命科学研究中所涉及的样品反应、检测、分析等过程得以连续化、集成化和微型化 ,现已成为当今生命科学研究领域发展最快的技术之一 .目前的生物芯片主要有核酸芯片、蛋白质芯片和糖体芯片等几大类 ;核酸芯片可测定基因表达情况或基因突变情况 ,同时也可测定多种疾病的相关基因 ;蛋白质芯片可直接从体液中检测特定蛋白质分子标记物 ,在肿瘤和传染性疾病的临床诊断领域里具有广阔的应用前景 ;糖体芯片则是最近创立的新型技术 。
The biochip technology is a novel parallel analytic method based on the recognition between bio-macromolecules, including nucleic acid and protein. Through the combination of technologies from micro-electronics, micro-mechanics and computer sciences it makes concatenation, integration and miniaturization of sample processing, signal detection and analysis in the study of life science biotechnique , It has become one of the fast developing biotechnology.Biochips can be divided into three categories: Gene chip, Protein chip, Sugar chip. The gene chip can determine the expression status of genes, or find the gene mutation, and it can be used for the diagnosis of inheritable diseases. Protein chip is to detect protein protein interactions, and it can directly measure the concentration of protein markers in blood sera and has a great value in diagnosis. Sugar chip technology is a new biotechnology arising in 2002. In the present age, the Lab-on-a-chip concept has been paid considerable attention.
出处
《中国计量学院学报》
2002年第3期229-234,共6页
Journal of China Jiliang University
