参麦注射液治疗原发性低血压临床观察

Efficacy treating essential hypotension with Shenmai Injection

目的 探讨参麦注射液治疗原发性低血压的疗效及其对血液动力学的影响。方法 采用随机单盲法,将78例原发性低血压患者分为2组,其中40例用参麦注射液治疗作为观察组,38例以维生素C静脉滴注为对照组,2组均连续用药4周。结果 观察组的显效率和总有效率分别为45.0％和95.0％;对照组为2.6％和10.5％,2组比较差异非常显著(P<0.01)。参麦注射液治疗后患者收缩压、舒张压、心排出量、心脏指数和射血分数均明显增加,与治疗前比较有非常显著性差异(P<0.01);与对照组比较亦有非常显著性差异(P<0.01)。治疗期间参麦注射液组未见不良反应。结论 参麦注射液是治疗原发性低血压的一种有效而安全的药物。

Objective To study the effect of Shenmai Injection (SMI)on essential hypotension and hemody-namic.Methods Patients(78 cases)with essential hypotension were divided randomly into trial group (40 cases)and control group(38 cases) .The trial group was received SMI for 4 weeks and the control group received Vitamin C injection for 4 weeks therapy in both continuously. Results The obvious effective rate and total effective rates were 45 % and 95% in trial group repectively,its were higher than those in control group(2.6% and 10.5%) ,there was obvious difference between 2 groups ( P < 0.01). At the same time, systolic blood pressure ( SBP), diastolic blood pressure (DBF) ,cardiac output(CO) .cardiac index(CI) , and ejection fiaction(EF)could be significantly increased( P < 0. 01) after the treatment of SMI. In trial group were superior to those in control group( P < 0.01) . Conclusion SMI is an effective and safe drug for treating essential hypotension.