摘要
目的 观察白细胞清除术联合化疗治疗高白细胞白血病的疗效。方法 使用CS3000 Plus血细胞分离机对23例高白细胞白血病患者进行白细胞清除术,术后进行化疗,同时选择14例同期高白细胞白血病患者单纯化疗作为对照,比较2者疗效。结果 经白细胞清除术后,患者外周血白细胞数较治疗前明显下降(P<0.001);所有患者的自觉症状显著改善,治疗组完全缓解率达47.8%,明显高于对照组(28.6%,P<0.01);治疗组早期病死率为17.4%,明显低于对照组(P<0.01)。结论白细胞清除术能迅速降低白细胞数,减轻高白细胞白血病患者化疗时引起的不良反应,提高化疗完全缓解率,是治疗高白细胞白血病的重要辅助方法。
Objective To observe the clinical effects of leukapheresis plus chemotherapy on hyperleukocytic leukemia( HL) . Methods Twenty - three patients with HL in treatment group received leukapheresis by using CS -3 000 Plus blood cell separator plus chemotherapy. Fourteen HL patients in control group were chosen to receive chemotherapy alone. Results After leukapheresis, the WBC count of all patients decreased significantly ( P < 0.001) . The symptoms of leukostasis were relieved in 23 cases. Complete remission( CR)rate of the treatment group (47. 8 % ) was significantly higher than that of control group (28.6%, P < 0.01) . Case - fatality rate( 17.4%) in early stage was significantly lower than that of control group( P < 0.01) . Conclusion Leukapheresis can reduce WBC count rapidly and improve symptoms of leukostasis in hyperleukocytic leukemia. Leukapheresis plus chemotherapy can increase the CR rate and reduce side effects of chemotherapy. It is an accessory treatment importantly.
出处
《疑难病杂志》
CAS
2002年第3期133-135,共3页
Chinese Journal of Difficult and Complicated Cases
关键词
白血病
白细胞清除术
化疗
白细胞淤滞
Hyperleukocytic leukemia
Leukapheresis
Chemotherapy
Leukostasis
