老年慢性肾功能不全伴高血压病患者血浆中利钾尿肽与心钠素的变化

Changes of kaliuretic peptide and atrial natriuretic peptide in aged patients with chronic renal failure

目的 探讨老年慢性肾功能不全 (CRF)伴高血压病患者血浆中利钾尿肽 (KP)与心钠素 (ANP)的变化。方法 选择老年CRFⅡ～Ⅲ期伴有高血压病的患者 2 6例 ;选择同期老年原发性高血压病 (EH) 1～ 3级高危患者而肾功能正常者 2 5例为对照组。应用超声心动图仪测量室间隔、左室后壁厚度、左室舒张末内径并计算出左室心肌重量 (LVM ) ;监测 2 4h动态血压 ,测出平均收缩压 (SBP)及舒张压 (DBP) ;同时测定血浆中的KP与ANP、血肌酐、尿素氮 ,进行统计学分析。结果 CRF组SBP ,DBP及LVM均高于EH组 ,而且KP ,ANP及KP ANP亦高于EH组 ,两组间有明显差异。结论 KP 。

Objective To approach the changes of plasma kaliuretic peptide(KP)and atrial natriuretic peptide(ANP) in aged patients with chronic renal failure (CRF) and hypertension. Methods Twenty six aged CRF(Ⅱ-Ⅲ stage) patients with hypertension,25 senile essential hypertension(EH,1-3 grade,high risk) patients with normal renal function were observed in the year 2000. The interventricular septum thickness (IVST), posterior wall thickness , end diastolic diameter of left ventricle and left ventricular mass(LVM) were measured. The average systolic and diastolic blood pressure(SBP,DBP) were measured with ambulatory blood pressure monitoring. At the same time, the levels of plasma KP and ANP,blood creatinine, blood urea nitrogen were also obtained, and all data were undergone statistical analysis. Results Not only SBP,DBP and LVM,but also the levels of plasma KP and ANP in the aged CRF group were significantly higher than those in the aged EH one.Conclusions The changes of plasma KP and ANP may play an important role in the pathogenesis and progression of hypertension in aged patients with CRF. [