肿瘤基因治疗中腺病毒载体的转导靶向
Transduction target of viral vector in gene therapy
摘要
重组DNA技术的发展使得肿瘤基因治疗的应用范围越来越广泛,已有部分代替那些传统疗法(外科手术、化疗和放疗)的趋势.但目前存在两个重要的问题需要解决:(1)现有的载体系统缺少组织特异性;(2)现行的基因疗法的基因转染的效率比较低.这在很大程度上制约了肿瘤基因治疗的应用.为了克服这两个难题,我们需要人工构建新型的,具有特异靶向及高效率转染等特性的载体系统.腺病毒作为目前基因治疗中常用的载体系统中的一员,对其的改造和修饰已引起了很多人的关注,而且也构建出了一些高效率的具有特异靶向性的腺病毒载体.在这里将详细的介绍这些新颖的腺病毒载体.
出处
《中国骨肿瘤骨病》
2002年第4期188-191,共4页
Chinse Journal Of Bone Tumor And Bone Disease
参考文献20
-
1[1]Jakubczak JL, Rollence ML, Stewart DA et al. Adenovirus type 5 viral particles pseudotyped with mutagenized fiber proteins show diminished infectivity of coxsackie B - adenovirus receptor - bearing cells. J Virol,2001,75: 2972 - 2981.
-
2[2]Wickham TJ, Roelvink PW, Brought DE, et al. Adenovirus targeted to heparan- containing receptors increase its gene delivery efficiency to multiple cell types. Nature Biotechnol, 1996,14:1750 - 1753.
-
3[3]Vanderkwaak TJ, Wang M, Gomez - Navarro J, et al. An advanced generation of adenoviral vectors selectively enhances gene transfer for ovarian cancer gene therapy approaches. Gynecol Oncol, 1999,74:227- 234.
-
4[4]Xia H, Anderson B, Mao Q, Davidson BL. Recombinant human adenovirus :targeting to the human transferrin receptor improves gene transfer to brain microcapillary endothelium. J Virol, 2000,74:11359 - 11366.
-
5[5]Alexander P, Larisa P, David TC. Phage Display of Adenovirus Type 5 Fiber Knob as a Tool for Specific Ligand Selection and Validation. J Virol,2001,7107 - 71013.
-
6[6]Bilbao G, Gomez- Navarro J, Curiel DT. Targeted adenoviral vectors for cancer gene therapy. Adv Exp Med Biol, 1998,451: 365 - 374.
-
7[7]Wickham TJ, Haskard D, Segal D, et al. Targeting endothelium for gene therapy via receptors up - regulated during angiogenesis and inflammation. Cancer Immunol Immunother, 1997,45(3 - 4): 149 - 151.
-
8[8]Wickham TJ, Lee GM, Titus JA, et al. Targeted adenovirus - mediated gene delivery to T cells via CD3. J Virol, 1997,71: 7663 - 7669.
-
9[9]Einfeld DA, Brough DE, Roelvink PW, et al. Construction of a pseudoreceptor that mediates transduction by adenoviruses expressing a ligand in fiber or penton base. J Virol, 1999,73:9130 - 9136.
-
10[10]Vigne E, Mahfouz I, Dedieu JF, et al. RGD inclusion in the hexon monomer provides adenovirus type 5 - based vectors with a fiber knob - independent pathway for infection. J Virol, 1999,73: 5156 - 5161.
-
1吴亮,董维,杨辉,林言华.羟基脲联合干扰素与马利兰治疗慢性粒细胞性白血病疗效对比[J].吉林医学,2015,36(5):833-834. 被引量：1
-
2丁矢,张艳平,杨杰.肺鳞癌基因的研究进展[J].中国医药指南,2013,11(31):355-356. 被引量：1
-
3张建业,庞维秋,王明运.重组DNA技术与肿瘤的临床诊断[J].国外医学（临床生物化学与检验学分册）,1990,11(6):5-8. 被引量：1
-
4黄伟,张卓军,吴雄辉.腹腔镜低位直肠癌保肛根治术98例分析[J].中国医药导刊,2014,16(4):600-601. 被引量：1
-
5邱志东,缪辉来,雷长江,刘忠考,黎然,包仕廷.靶向磷脂酰肌醇蛋白聚糖3的小干扰RNA筛选和对肝癌细胞的作用[J].中华实验外科杂志,2012,29(9):1727-1729. 被引量：3
-
6冯丽娜(综述),刘鉴峰(审校),张春明(审校).多肽用于肿瘤治疗的研究进展[J].国际肿瘤学杂志,2010,37(9):643-646.
-
7吕爱兰,徐文,徐霞.3种方法治疗宫颈高危型HPV感染的疗效比较[J].浙江医学,2017,39(7):551-554. 被引量：7
-
8杨晓葵.人类卵巢癌基因治疗的新进展[J].国外医学（妇产科学分册）,1998,25(5):282-285.
-
9张清媛.癌症的基因治疗[J].实用肿瘤学杂志,1998,12(2):157-160.
-
10范江,曾毅,M.Motz,H.Wolf.EB病毒壳抗原在大肠杆菌中的表达及纯化[J].中国医学科学院学报,1989,11(5):381-387.
