2-甲基-2-乙基-1,3-丙二胺的合成研究

Synthesis of 2-methyl-2-ethyl-1,3-propanediamine

首先以丁酮和硝甲基烷为原料,哌啶作催化剂,合成2-甲基-2-乙基-1,3-二硝基丙烷,然后采用铁和盐酸进行还原,得到题目化合物,并对反应条件进行研究,得出了较佳的反应条件,产率达81.2%。

Firstly, 2-methyl-2-ethyl-1,3-dinitropropane was prepared with butanone and nitromethane in the presence of piperidine as catalyst. Then it was reduced to the title compound with iron and hydrochloric acid. The optimum reaction conditions were found by research, and the ratio of target to title compound was 81.2%.