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PTCA术后再狭窄防治进展

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摘要 经过20余年的临床发展和应用,经皮冠状动脉腔内血管成形术(PTCA)日趋成熟,成功率可达90%以上,但术后6个月仍有30%~50%的再狭窄(RS)率 [1],严重影响了其疗效.因此研究RS的发生机制和防治方法是当前一大热点和难点.目前研究表明RS发生机制是:①血管平滑肌细胞(SMC)的迁移和增殖;②血小板的聚集、黏附和生长因子的释放;③炎症反应;④血管弹性回缩和重构(Remodeling).因为RS发病因素是多方面的,因此RS的防治应采取个体化的多维综合措施.现在对RS防治研究主要集中在全身(或局部)用药、新器材新技术的应用上,本文就这方面的进展进行综述.
机构地区 武警 武警总医院
出处 《华南国防医学杂志》 CAS 2002年第5期17-19,共3页 Military Medical Journal of South China
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