微血管密度与子宫内膜癌关系的研究

The study of the density of microvessels in endometrial carcinoma

目的 探讨微血管密度(MVD)与人子宫内膜癌的临床病理特征和无瘤生存率的关系;方法 采用免疫组织化学方法检测34例子宫内膜癌组织中.MVD的表达水平;结果 在肿瘤直径≥2cm的MVD高密度率高于肿瘤直径<2 cm(84.62％VS 66.67％,P=0.1300 4);Ⅲ期MVD的高密度率明显高于Ⅰ期和Ⅱ期的总MVD高密度率(100.00％VS 74.74％,P=0.001 0);MVD在发病年龄<50岁的高密度率明显高于发病年龄≥50岁(100.00％VS78.33％.P=0.016 0);34例患者有3例有淋巴结转移,其MVD均为高密度;NVD与病理分级、无瘤生存率无关。结论子宫内膜癌中MVD可能具有促肿瘤生长、转移的作用并具有年龄依赖性。

Objective To study the relationships between the expressions of the density of microvessels (MVD) of the tumors and the clinicopathologic features, disease - free survival rates in endometrial carcinoma. Methods Specimens from 34 cases of endometrial carcinoma were studied by immunohistochemical stainings with monoclonal antibodies to MVD. Results MVD high- density rates were found higher in the following cases, tumor size ^2 cm than in that < 2 cm (84.62% vs 66.67% , P =0.000 4) , stage Ⅲ than in stage Ⅰ-Ⅱ (100.00% vs 74.74% , P = 0.001 0) and age < 50 than in age≥50 (100.00% vs 78.33% , P = 0.016 0) . 3 cases with lymph node metastasis all showed high- density MVD. There was no significant correlation between MVD and histologic grade or disease - free survival rate. Conclusions MVD was associated with tumor growth , metastasis and was age - dependent in endometrial carcinoma.