卵巢上皮性肿瘤患者血清与腹水LN、HA含量变化及临床意义

Detection of LN, HA in serum and ascites from patients with epithelial ovarian tumor

目的 研究卵巢上皮性肿瘤患者血清与腹水细胞外基质成分层粘蛋白(Laminin,LN)、透明质酸(Hyaluronic Acid,HA)含量变化及临床意义。方法采用放射免疫法测定75例卵巢上皮性肿瘤患者及42例对照组血清术前及术后LN、HA含量,并测定其中22例恶性肿瘤腹水LN、HA含量。结果恶性卵巢上皮性肿瘤组术前血清LN、HA含量显著高于对照组及良性肿瘤组(P<0.01,P<0.05),术后明显下降,手术前后血清LN、HA含量差异有显著性意义(P<0.05);卵巢恶性肿瘤患者低度分化组血清LN、HA含量显著高于中度及高度分化组(P<0.05),腹水LN、HA均显著高于血清含量(P<0.05),二者之间呈显著正相关(r分别为0.79、0.82,P<0.05),淋巴结转移组血清LN含量显著高于无淋巴结转移组(P<0.05,P<0.01)。结论LN、HA与肿瘤的生物学特性密切相关,其血清及腹水含量对于病情判断及监测具有重要的临床意义。

Objective To investigate the laminin (LN) and Hyaluronic Acid (HA) levels of serum and ascites in epithelial ovarian tumor . Methods Serum and ascites samples from 75 patients with epithelial ovarian tumor and 42 cases as control group were analyzed by radioimmunoassay. Results The results showed that the LN and HA levels of serum in patients with malignant tumors were significantly higher than those in control group and in patients with benign tumors ( P < 0.01, P < 0.05) before operation. The serum levels of malignant group decreased significantly after operation. The serum levels of LN and HA in low - differentiated tumors were higher than those in moderate - differentiated rumors and high - differentiated tumors (P < 0.05) .The LN, HA levels of ascites were higher than that of serum ( P < 0.05) in malignant tumors. The serum levels with lymph node metastasis were higher than that without lymph node metastasis (P<0.05, P<0.01) .Conclusions LN and HA in serum and ascites expressed higher in malignant epithelial ovarian tumors than benign group. This investigation revealed that LN and HA are important diameters reflecting tumor biological characteristics.