米非司酮用于围绝经期功能性子宫出血治疗的临床观察

Effect of Mifepristone on perimenopausal dysfunction uterine bleeding

目的探讨米非司酮治疗围绝经期功血的效果。方法将确诊为围绝经期功血的患者16人,口服米非司酮10mg,每日晨空腹服用,连服6个月,于治疗前及治疗过程中用B超监测子宫内膜厚度及血清内分泌六项、肝肾功能等指标。结果患者在服药期间均闭经,雌激素水平降低,无子宫内膜增厚,其他监测指标无明显改变。结论 口服低剂量米非司酮对围绝经期功血疗效肯定,是一种可行的治疗方法。

Objective To study the effect of Mifepristone on dysfunctional uterine bleeding in perimenopausal. Methods Sixteen patients with perimenopausal dysfunctional uterine bleeding received lower dose Mifepristone (10 mg/day for six months) . Pre - and post - therapy, thickness of the endometrium measured by B - ultrasonography, sera hormone concentration and biochemical evaluation related to the function of liver and kidney were analyzed. Results AD of the patients developed amen-orrhea, E2 reduced and no thickened of the endometrium during the treatment. The other items examined did not change obviously. Conclusions Oral low dose Mifeprostone is an efficient and feasible therapy for the perimenopausal dyefuntional uterine bleeding.