p27与cyclin E蛋白在宫颈鳞癌中的表达及临床意义

Expressions and clinical significance of p27 and cyclin E proteins in cervical squamous cell carcinoma

目的 研究细胞周期相关蛋白p2 7与cyclinE在宫颈鳞癌中的表达及其与组织学分级、临床分期及预后的关系。方法 应用SP免疫组化法检测 5 4例宫颈鳞癌中p2 7和cyclinE蛋白的表达 ,分析它们的阳性表达与肿瘤的组织学分级、临床分期及预后的关系。结果 P2 7蛋白在宫颈鳞癌中呈低表达 ,且与组织学分级和预后有关 ;而cyclinE蛋白在宫颈鳞癌中呈高表达 ,且与临床分期和预后有关。两者在肿瘤中的表达呈负相关。低p2 7、高cyclinE表达预示患者有一个不良的预后。结论 p2 7和cyclinE蛋白与宫颈鳞癌的发生、发展有关。p2 7与分化有关 ,cyclinE与病程进展有关 。

Objective To investigate the expressions of p27 and cyclin E proteins in cervical squamous cell carcinoma, and discuss the relationship between their expressions and tumor's histological and clinical grades, as well as patients prognosis. Methods P27 and cyclin E protein expressions in 54 cases of cervical squamous cell carcinoma were examined by immunohistochemical method. The relationship between their expressions and the tumor's histological and clinical grades, and patient's prognosis were analyzed using a χ 2 test. Results Low expression of p27 was observed in cervical squamous cell carcinoma, which was correlated with tumor cell's histological grade and patient's prognosis.In contrast, high expression of cyclin E was observed in cervical squamous cell carcinoma, which was correlated with clinical grade and patient's prognosis.There was a reverse correlation between p27 and cyclin E expressions.A combination of decreased expression of p27 and the increased expression of cyclin E indicated a poor clinical prognosis. Conclusions The interaction of p27 and cyclin E proteins might contribute to the progression of cervical squamous cell carcinoma.Their expressions could be served as useful markers for predicting prognosis.