β-内酰胺酶抑制剂研究进展

The Reseach progess in 13 -Lactamase Inhibitors

报道了4种β-内酰胺酶抑制剂(包括克拉维酸、舒巴坦、他唑巴坦以及BRL-42715)的特性、各抑制剂的复方制剂、作用 机制,以及这些酶抑制剂与不耐酶的β-内酰胺类抗生素联合应用后的协同作用,并对酶抑制剂抑酶作用进行了比较。

The characteristics, complex preparation of every Inhibitors, mechanism of fourβ -Lactamase Inhibitors(including clavulanic acid, sulbactanu tazobactam and BRL-42715), and the synergistic action after coordinated application between these β -Lactamase Inhibitors and β -Lactam antibiotics have been reported. The enzymatic inhibition of the enzyme inhibitor was also compared.