药物性肝损害75例分析

Analysis of 75 cases of drug induced liver disease

目的:提高对药物性肝损害的认识,减少其发病率。方法:对75例药物性肝损害的临床资料进行回顾性分析。结果:致肝损害的药物种类繁多,以中药为最多(21.3％),其次为抗结核药(16％);其临床主要表现为疲乏、食欲减退、恶心、呕吐、腹胀(84％),其次为黄疸(58.7％);肝功能受损以ALT、r-GT、TBiL增高为主;临床治愈40例(53.3％),好转33例(44％),恶化自动出院2例(2.7％)。结论:临床上慎用对肝脏有损害的药物,用药期间严密观察,肝功能检查是早期诊断的主要方法,早期及时停用肝损害的药物是治疗的关键。

Objective: To improve the cognition on drug induced liver disease(DILD) and decrease its occurrence. Methods: The retrospective study on the clinical data of 75 cases of DILD was carried out. Results: There were many medicines that could lead to liver lesion,but in which Chinese herbal medicines were the most (account for 21.3%), and followed by antituberculous drugs (16%); the fatigue, anorexia,nausea,vomiring and abdominal distension were principal clinical manifestations ( 84%) ,and followed by the jaundice (58.7%);ALT,r-GT and TBiL were high after liver function lesion;40 patients were cured (53.3%),33 patients were improved (44%) ,and 2 patients left hospital due to exacerbating hepatitis (2.7%). Conclusions: The drugs that can cause liver injury should be used and observed carefully careful observation during the treatment.The major means for its early detection is liver function test .The principal management for the disease is discontinuation of the suspected drugs.