空心莲子草醇提物对D-半乳糖胺诱导的肝损伤的影响

Effects of alternanthera philoxeroides on hepatic iniurv induced bv D - galactosamine

目的:考察空心莲子草醇提物是否对受损肝功能有影响。方法:将小鼠随机分成六组,正常对照组:生理盐水0.1 ml·10g-1,ip;模型组:D-半乳糖胺0.5g·kg-1,ip;阳性组:联苯双酯0.2g·(kg·d)-1,ig;空心莲子草醇提物高剂量组:40g·(kg·d)-1,ig;中剂量组20g·(kg·d)-1,ig小剂量组:10g·(kg·d)-1,ig;空心莲子草醇提物连续给药3天。测定各组动物血清中ALT及AST,并取肝脏作病理组织学检查。结果:空心莲子草醇提物能明显降低南D-半乳糖胺引起的小鼠血清AST、ALT活性升高。且以中剂量作用最为明显,并能减轻肝细胞损伤。结论:空心莲子草醇提物可有效对抗D-半乳糖胺诱导的小鼠肝损伤。

Objective: To observe the protective effects of alternanthera philoxeroides on hepatic injury induced by D-Galactosamine . Method: The experimental mice were divided into six groups and were respectively given physiological saline (0.1 m 1 ·10g-1, ip,control group ), D- Galactosamine (0.5g ·kg-1,ip, model group ),bifendate 0.2g · ( kg · d )-1,ig,BIF group) and alternanthera philoxeroides [40g ·(kg · d)-1 、20g·(kg ·d)-1、10g · (kg · d)-1, ig, separately, APG group].The hepatic injury model was induced by D-Galactosamine.Serum ALT、AST and hepatic pathological changes were examined.The effects of altemaninthera philoxeroides on hepatic injury mice were observed. Results: Alternanthera philoxeroides could obviously reduce the level of ALT and AST induced by D-Galactosamine . Conclusion: Alternanthera philoxeroides has the protective effect on hepatic injury induced by D- Galactosamine .