不同厂家头孢氨噻肟粉针剂在输液中的稳定性

Study on the stability of cefotaxime made in three factoris mixed with transfusion

目的:考察不同厂家头孢氨噻肟粉针剂的稳定性。方法:采用高效液相色谱法进行含量测定及稳定性比较。NovapakC18色谱柱(3.9×150mm× 5μm),流动相:磷酸缓冲液(磷酸二氢钾60mg+磷酸氢二钠1.2g加水到1000mL),甲醇(1000:120),流速1.5ml·min-1,内标 甲硝唑2mg·min-1,柱温30℃,检测波长:254nm。结果:回归方程A=0.03965C-0.02175(r=0.9998),头孢氨噻肟在浓度5.245-31.47μg·mL-1范围内呈良好的线性关系。结论:三个厂家的头孢氨噻肟粉针的质量没有明显的差异。

Objective: To study the stability of CTX made in three factory.Methods: RP-HPLC was applied for quantitative analysis ,using as an internal standard(IS) ,Novapak C18 Column(3.9mmX 15mm ,5 μm) was used .The mobile phase was consisted of peposite buffer-MethanoI acid (1000:120).The flow rate 1.0 ml·min-1and the UV detection wavelength was 254nm.Results:Regression equation was A=0.03965C-0.02175(r=0.9998),it had a good linear relation when the consentration range of CTX was 5.245-31.47 μg ·mL-1.Conclusion:The stability of CTX made in three factories is not was different.