PPAR基因在脊椎动物发育过程中的功能研究

PPAR expression and function during vertebrate development

过氧化物酶体增殖剂激活受体(peroxisome proliferstor activated receptor,PPAR)是核激素受体家族中的配体激活受体,在不同的物种中已经发现了它的3种亚型,即PPARα、PPARβ(也有称δ)和PPARγ。通过结合到相应的激活剂上,这些受体在一些重要的代谢途径中刺激靶基因的表达。本文是就PPAR在一些脊椎动物胚胎发育过程中的功能方面作一综述。PPAR的功能表现在脂肪组织、脑组织、胎盘和皮肤的分化方面。

The peroxisome prolifentor activated receptors (PPARδ) are ligand activated receptors which belong to the nuclear hormone receptor family. Three different PPAR isotypes (PPARα.PPARβ,also called PPARδ.and PPARγ) have been identified in various species.Upon bmding to an activator, these receptors stimulate the expression of target genes implicated in important metabolic pathways.The present article is a review of PPAR involvement in some aspects of Xenopus lae-vis and rodent embryonic development. PPARδ are implicated in several aspects of tissue differentiation and rodent development, such as differentiation of the adipose tissue,brain,placenta and skin.Particular attention is given to implication of PPARα and PPARβ in rodent epidermal differentiation.