摘要
研究了苯乙酮在负载型铑催化剂催化下的多相不对称氢化反应,结果表明在以1%Rh-γ-Al2O3-2TPPTS和1%Rh-SiO2-2TPPTS为催化剂,(1S,2S)-二苯基乙二胺(DPEN)为手性修饰剂和一定量的KOH用于苯乙酮的不对称加氢反应,在反应条件为40oC,5MpaH2下,显示出好的催化活性,苯乙酮加氢产物的对映选择性分别达到了22.5%和25.4%。
The enantioselective hydrogenation of acetophenone in the presence of γ-Al2O3 or SiO2 Supported Rhodium,TPPTS,chiral modifier(1S,2S)-DPEN was investigated. The effects of different support,temperature,hydrogenation pressure on the asymmetric hydrogenation of acetophenone have been studied. Under the reaction conditions of 40oC,5.0Mpa H2 in 2.0ml KOH/i-PrOH (0.045mol/L) solution for 3h,the conversion of acetophenone and the e.e. value of product are 100% and 25.4%,respectively. It was observed that (1S,2S)-DPEN not only played a key role in the chiral inducement, but also accelerate the reaction.
关键词
苯乙酮
催化剂
不对称加氢
对映选择性
acetophenone
catalyst
enantioselective hydrogenation
asymmetric hydorgenation
