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抗藻酸盐血清对粘液型铜绿假单胞菌生物被膜杀菌活性的影响

The influence of anti- bacterial activity of the anti- alginate serum on the mucoid Pseudomonas aeruginosa biofilm
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摘要 目的:研究抗藻酸盐血清与加替沙星的联合作用对粘液型铜绿假单胞菌生物被膜杀菌活性的影响.方法:采用MTT方法测定粘液型铜绿假单胞菌生物被膜活菌数,用微量稀释法测定抗生素对其的最低生物被膜清除浓度(MBEC).结果:1:1抗藻酸盐血清与1×MIC、4×MIC和8×MIC加替沙星联用可以使细菌生物被膜中的活菌数从6.63±0.85、6.48±1.12和5.73±1.10 1g(cfu/cm2)显著降低至5.76±0.90、5.02±0.93和4.70±0.621g(cfu/cm2),使加替沙星对铜绿假单胞菌的最低生物被膜清除浓度从8μg/ml降低至4μg/ml.结论:抗藻酸盐血清与加替沙星联用后,能够增强抗生素对于生物被膜的杀菌活性.
出处 《中国药物应用与监测》 CAS 2001年第6期24-27,共4页 Chinese Journal of Drug Application and Monitoring
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