1[1]XiaoF, IVSF, XuSY, et al. Leflunomide, anewdisease- modiying drugs for treating active rheumatoid arthritis in Phase Ⅱmethotrexate-controlled clinical trial [J]. Chinese Medicine,2001, in press.
6[6]Kalden J, SChattenkirch M, Smonlen L et al, Lefiunomine Vs. sulfasalazine in rheumatoid arthritis: 24 month updme Of a randomized double blind study[J]. Arthritis Rheum, 1999,42(9 Suppl): S271. Abstract 1202.
7[7]Sharp J,Strand V,Leung H. et al. Treatment. With leflunomtde Slows radinographic progression of rheumatoid arthritis[J]. Arthritis Rheum, 2000,43(3):495-505.
二级参考文献13
1[1] Barlett RR,Anagnostopulos H,Zielinski T,et al.Effects of leflun o mide on immune responses and models of inflammation.Springer Semin Immunopathal, 1993,14∶381-394.
2[2] Weaver A, Caldwell J, Olsen N et al. Treatment of active rheumat oid arthritis with leflunomide compared to placebo or methotrexate. ACR Concurre nt Session，1998, Abstract∶593.
3[3] Finnegan A,Siemasko K F,Williams J W，et al.Leflunomide inhibits immunog lobin prodution by two separate mechanism.ACR Poster Session,1997,40.
4[4] Barlett R.R，et al. Leflunomide, an imunorestoring drug for the therapy autoimmune disorders, especially rheumatoid. Current Opinion in Rheumatoid， 199 7，9∶410.
5[5] Prakash M, Jarvis B. Leflunomide, a review of its use in active rheumat oid arthritis.1999,58(6)∶1137-1164.
6[6] Weinblatt ME, Kremer JM, Coblyn JS，et al. Leflunomide plus methotrexate in refractory rheumatoid arthritis: A pilot study. ACR Poster Session，1997,Abs tract∶974.
7Smolen SJ,Kalden RJ,Scott LD,et al.Efficacy and safety of leflunomide compared with placebo and sulphasalazine in active rheumatoid arthritis: a doubleblind, randomised, multicentre trial[].The Lancet.1999
8Fox RI.Mechanism of action of leflunomide in rheumatoid arthritis[].The Journal of Rheumatology.1998
9Smolen JS,Kalden JR,Scott DI,et al.Efficacy and safety of leflunomide compared with placebo and sulphsalazine in active rheumatoid arthritis: a doubleblind, randomised, multicentre trial[].The Lancet.1999
10Fox RI.Mechanism of action of leflunomide in rheumatoid arthritis[].Journal of Rheumatology The.1998
