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维甲酸自乳化制剂的含量测定及体外溶出评价

Drug content determination and dissolution evaluation of retinoid self - emulsifying drug delivery system in vitro
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摘要 目的:研究维甲酸RA自乳化制剂的含量测定方法及体外溶出行为。方法:采用HPLC法测定维甲酸RA自乳化制剂的药物含量,与市售胶囊比较,考察RA自乳化制剂体外溶出行为。结果:与市售胶囊剂相比,以水为溶出介质,维甲酸RA自乳化制剂15min可以溶出80%以上,而市售胶囊只溶出不到5%。自乳化制剂可以显著提高药物的体外溶出。 Objective: To investigate the determination method and dissolution behavior of retinoid self - emulsifying drug delivery system in vitro. Method: Determine retinoid in self - emulsifying preparation by HPLC and evaluate dissolution behavior compared with market capsule. Result: Retinoid in self - emulsifying preparation dissolute 80% at 15min but 5% in market capsule. The self- emulsifying drug delivery system improved drug dissolution significantly.
作者 陆燕 全东琴
出处 《中国药物应用与监测》 CAS 2004年第2期57-59,共3页 Chinese Journal of Drug Application and Monitoring
关键词 自乳化释药系统 药动学 体外溶出 SEDDS Pharmacokinetics Dissolution in vitro
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参考文献5

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