维甲酸自乳化制剂的含量测定及体外溶出评价

Drug content determination and dissolution evaluation of retinoid self - emulsifying drug delivery system in vitro

目的:研究维甲酸RA自乳化制剂的含量测定方法及体外溶出行为。方法:采用HPLC法测定维甲酸RA自乳化制剂的药物含量,与市售胶囊比较,考察RA自乳化制剂体外溶出行为。结果:与市售胶囊剂相比,以水为溶出介质,维甲酸RA自乳化制剂15min可以溶出80％以上,而市售胶囊只溶出不到5％。自乳化制剂可以显著提高药物的体外溶出。

Objective: To investigate the determination method and dissolution behavior of retinoid self - emulsifying drug delivery system in vitro. Method: Determine retinoid in self - emulsifying preparation by HPLC and evaluate dissolution behavior compared with market capsule. Result: Retinoid in self - emulsifying preparation dissolute 80% at 15min but 5% in market capsule. The self- emulsifying drug delivery system improved drug dissolution significantly.