2003年264例抗感染药不良反应报告分析

Analysis of 264 cases of anti-infectives adverse reaction reports in 2003

目的:描述我院抗感染药物发生的ADR情况。方法:对我院2003年度264例ADR病例报告进行了分类统计和分析评价。结果:ADR共涉及32种抗感染药物,其中氟喹诺酮类居首位,其次为头孢菌素类。合并用药占22.7％,给药途径以静脉用药为主。主要的ADR类型为皮肤损害,其次是胃肠系统损害。重度ADR共11例。结论:应加强抗感染药物的安全性评价,尤其应重视不易观察及慢性ADR的监测。

Objective:To describe the situation of anti-infectives adverse reactions in our hospital. Methods: Our hospital's 264 cases of ADR reports of anti-infectives in 2003 were classified, analysed and evaluated. Results:32 kinds of drug developed ADRs, the occurrence of fluoroquinolones was the first, cephalosporins the second. The incidence of combined use of drugs was 22.7%.The dosages given by vein were the majority. The main types of ADRs were skin damages, next were gastro-intestinal damages. 10 cases were caused by serious ADRs. Conclusion: Save evaluation to anti-infectivs should be given more ,especially the ADRs difficult to observe and chronic ADR should be paid more attention to.