^(18)F-FDG-hPET/CT显像在鼻咽癌诊治中的应用

Application of ^(18)F-FDG-hPET/CT in diagnosis and treatment of NPC

目的 初步探讨18F FDG hPET/CT双探头符合线路在鼻咽癌诊治中的应用。方法 17例鼻咽癌病人放疗前 (11/ 17例 )、放疗 5 0Gy～6 0Gy时 (10 / 11例 )、放疗后 3个月以上 (6 / 17例 )行18F FDG hPET/CT检查 ,测定靶 /非靶比值 (T/N)进行半定量分析。结果 11例鼻咽癌病人放疗前hPET/CT显示鼻咽部及受累淋巴结T/N分别为 3 5 8± 1 5 9和 4 5 5± 1 34;10 / 11例放疗中复查病人原发灶和受累淋巴结T/N分别为 1 36± 0 4 8和 1 17± 0 4 2 ;疗中与疗前相比 ,有统计学意义 (P <0 0 5 )。对 6例放疗后评价是否有残存或复发的病人 ,hPET/CT检查明确了CT或MRI不能确诊的病变 ,均经随访或病理证实。结论 18F FDG hPET/CT显像通过CT的解剖定位作用可以提高对病变的确诊率。

Objective To assess the application of 18 F-FDG-hPET/CT in diagnosis and treatment of nasopharyngeal carcinoma(NPC).Methods 17 NPC patients underwent 18 F-FDG-hPET/CT imaging.11/17 patients was performed before radiotherapy(RT),of which 10 patients after 50～60Gy radiation.6/17 patients was performed 3 months after completion of RT.The images were quantitatively analyzed by calculating tumor/non-tumor(T/N).Results The mean pre-RT T/N value of nasopharyngeal primary tumor and involved lymph nodes of 11 patients was 3.58±1.59 and 4.55±1.34,respectively.The mean mid-irradiation T/N value of 10 patients was 1.36±0.48 and 1.17±0.42,respectively.The difference between pre-RT and post-RT was significant(P<0.05).For 6 patients to differentiate recurrent or residual NPC from benign lesions,hPET/CT confirmed indeterminate CT or MRI findings.Conclusion 18 F-FDG-hPET/CT can improve diagnosis for NPC patients by CT anatomic location.