摘要
目的探讨抗凋亡蛋白survivin在乳腺癌组织中的表达及其与紫杉醇化疗敏感性的关系。方法应用免疫组化方法,对40例用紫杉醇化疗的乳腺癌患者癌组织survivin表达情况进行检测,分析其与紫杉醇化疗敏感性的关系。结果乳腺癌患者survivin表达阳性率为60.0%(24/40);survivin阴性组患者紫杉醇化疗后完全缓解率、有效率、控制率和获益率分别为50.0%、68.8%、93.8%和81.3%,survivin阳性组患者分别为25.0%、45.8%、75.0%和62.5%,两组相比各项指标均有显著差异(P<0.05)。结论survivin表达水平与乳腺癌对紫杉醇化疗敏感性呈显著负相关,sur-vivin可能作为一项预测紫杉醇疗效、筛选乳腺癌化疗药物、指导制定合理治疗方案的新指标。
Objective To study the correlation between chemosensitivity of pacilitaxel and the expression levels of anti-apoptotic protein survivin in breast cancer tissues.Methods The expressions of survivin in 40 samples of human breast cancer with pacilitaxel chemotherapy were detected by the immunohistochemical staining,and the results were related to chemosensitivity of pacilitaxel.Results The positive expression rate of survivin was 60.0%(24/40).The complete remission rate(50.0%),remission rate(68.8%),overall disease control rate(93.8%)and clinical benefit response rate(81.3%)in patients with negative survivin expression were significantly higher than those with positive survivin expression.There was a statistical significance in chemosensitivity of pacilitaxel between negative survivin and positive survivin group(P<0.05).Conclusion The survivin expression was negatively related to the sensitivity of human breast cancer cells to pacilitaxel.The survivin might be a valuable new marker in selecting chemical drugs、guiding the plan of rational therapeutic scheme in human breast cancer.
出处
《癌症进展》
2005年第6期587-589,595,共4页
Oncology Progress
基金
河南省科技创新人才工程项目基金资助(编号200479)
