彩色多普勒超声与临床实验在妊高征监测中的应用

The use of color doppler ultrasound in monitoring and radioimmunoassay β_ 2-MG for pregnancy induced hypertension

目的 探讨彩色多普勒超声检测肾内小动脉血流频谱和放免测定血、尿中 β2 -微球蛋白在妊高征者中的变化 ,为妊高征的早期诊断及治疗 ,评估预后提供敏感可靠的指标。材料与方法 99例孕产妇分成正常妊娠组 46例、妊高征组5 3例 ,分别于产前检测血和尿 β2 -微球蛋白 ,重度妊高征同时产前彩超监测肾小动脉多普勒血流频谱变化。结果 产前重度妊高征彩超肾小动脉S/D为 2 .38,明显高于正常妊娠组 ,P <0 .0 1;血、尿β2 -MG明显高于正常妊娠组 ,P <0 .0 1。结论 RIAβ2 -MG和彩超检测肾小动脉血流频谱可早期发现妊高征轻度肾脏损害 ,并估价妊高征预后 ,对于减少孕产妇围产期并发症具有重要意义。

Purpose To investigate the changes of the intrarenal small artery blood flow waveforms and radioimmunoassay (RIA)beta 2-microglobulin(β 2-MG)in blood and urine in pregnancy induced hypertension(PIH)women,give a sensitive and reliable indicator for the early diagnosis,treatment and evaluation prognosis in PIH women.Materials and methodsNinety-nine pregnant women are divided two groups,normal pregnancy group(n=46)and PIH gruoup(n=53).Determining β 2-MG in blood and urine before delivery,monitering the changes of the intrarenal small artery blood flow waveforms in partial PIH women.ResultsThe systolic-diastolic ratio(S/D)of intrarenal small artery by color dopplor=2.38,is higher than the normal pregnancy group,P<0.01.Blood and urine β 2-MG in the severe PIH women is significantly higher than in normal pregnant women,P<0.01.Conclusion We could find the earlier slight renal damage in PIH women and evaluate prognosis of PIH by color doppler ultrasound and the use of radioimmunoassay β 2-MG.It is very important for reduced the complications of perinatal women.