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Hepcidin在铁代谢调节中的作用

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摘要   铁是人体必需的微量元素,存在于所有细胞内.铁在体内除参与血红蛋白的合成和氧的运输外,还参加一些生物化学过程,包括线粒体的电子传递、儿茶酚胺代谢及DNA的合成.约半数参加三羧酸循环的酶和辅酶均含有铁或需铁的存在,铁缺乏会影响各种细胞的功能,造成人体多方面的功能紊乱.……
出处 《重庆医科大学学报》 CAS CSCD 2007年第z1期47-49,共3页 Journal of Chongqing Medical University
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参考文献23

  • 1[1]Fleming RE,Sly WS.Hepcidin:a putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease[J].Proc Natl Acad Sci USA,2001;98:8160-8162.
  • 2[2]Fleming RE,Sly WS.Mechanisms of iron accumulation in hereditary hemochromatosis[J].Annu Rev Physiol,2002;64:663-680.
  • 3[3]Mckie AT,Marciani P,Rolfs A,et al.An iron-regulated ferric reductase associated with the absorption of dietary iron[J].Science,2001 ;291:1755-1759.
  • 4[4]Gunshin H,Mackenzie B,Berger UV,et al.Cloning and characterization of a mammalian proton-coupled metal-iron transporter[J].Nature,1997; 388:482-488.
  • 5[5]Donovan A,Brownlie A,Zhou Y,et al.Positional cloning of zebrafish ferroportinl identifies a conserved vertebrate iron exporter[J].Nature,2000; 403:776-781.
  • 6[6]Vulpe CD,Kuo YM,Murphy TL,et al.Hephaestin,a ceruloplasmin homologue implicated in intestinal iron transport,is defective in the sla mouse[J].Nat Genet,1999;21:195-199.
  • 7[7]Nicolas G,Bennoun M,Devaux I,et al.Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor2(USF2) knockout mice[J].PNAS,2001; 98:8780-8785.
  • 8[8]Qian ZM,Li HY,Sun HZ,et al.Targeted drug delivery via the transferrin receptor-mediated endocytosis pathway[J].Pharmacol Rev,2002; 54:561-587.
  • 9王元忠,周建新.Hepcidin:具有抗菌活性的铁调节激素[J].生理科学进展,2005,36(4):372-375. 被引量:7
  • 10[12]Krause A,Neitz S,Magert HJ,et al.LEAP-1,a novel highly disulfide-bonded human peptide,xhibits antimicrobial activity[J].FEBS Letters,2000;480:147-150.

二级参考文献10

  • 1Park CH,Valore EV,Waring AJ,et al. Hepcidin,a urinary antimicrobial peptide synthesized in the liver.J Biol Chem,2001,276:7806~7810.
  • 2Nicolas G,Bennoun M,Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upsteam stimulatory factor 2(USF2) knockout mice.Proc Natl Acad Sci USA,2001,98:8780~8785.
  • 3Nicolas G,Bennoun M,Porteu A, et al.Sever iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA, 2002,99:4596~4601.
  • 4Nicolas G,Viatte L,Lou DQ, et al.Constitutive hepcidin expression prevents iron overload in a mouse model of hemocromatosis.Nat Genet,2003,34:97~101.
  • 5Laftah AH,Ramesh B,Simpson RJ, et al.Effect of hepcidin on intestinal iron absorption in mice.Blood,2004,103:3940~3944.
  • 6Clarke AT, Cadet E, Bomford A, et al. Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. Hum Mol Genet,2003,12:2241~2247.
  • 7Jacolot S,Gac GL,Scotet V. HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype.Blood,2004,103:2835~2840.
  • 8Papanikolaou G, Samuels ME, Ludwig EH, et al. Mutations in HFE2 cause iron overload in chromosome 1q linked juvenile hemochromatosis. Nat Genet,2004, 36:77~82.
  • 9Nemeth E,Vatore EV,Territo M, et al.Hepcidin,a putative mediator of anemia of inflammation,is a type Ⅱacute-phase protein.Blood,2003,101:2461~2463.
  • 10Nemeth E,Rivera S,Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest,2004,113:1271~1276.

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