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关于MxA蛋白抗病毒作用及其机制的研究进展 被引量:2

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摘要   MxA蛋白是由Ⅰ型干扰素(IFN-α/β)诱导产生的、属于动态蛋白超家族的一类大分子GTPase,除了具有这一类蛋白的共性外,其最大的、独有的特性在于:对于一系列RNA病毒、双链DNA病毒等有广谱的抗病毒活性.实验还发现:MxA基因启动子区域的多态性很大程度上影响了它的抗病毒作用.本文对MxA蛋白的抗病毒活性、机制以及影响因素研究进展进行综述,以指导临床病毒感染的诊断和治疗.……
作者 黄琴 许红梅
出处 《重庆医科大学学报》 CAS CSCD 2007年第z1期130-131,134,共3页 Journal of Chongqing Medical University
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  • 1Ganem D, Prince AM. Hepatitis B virus infection-natural history and clinical consequences. N Engl J Med, 2004, 350:1118-1129.
  • 2Fattovich G. Natural history and prognosis of hepatitis B. Semin Liver Dis, 2003, 23: 47-58.
  • 3Suzuki F, Arase Y, Suzuki Y, et al. Single nucleotide polymorphism of the MxA gene promoter influences the response to interferon monotherapy in patients with hepatitis C viral hffection. J Viral Hepat, 2004, 11: 271-276.
  • 4Gordien E, Rosmorduc O, Peltekian C, et al. Inhibition of hepatitis B virus replication by the interferon-inducible MxA protein. J Virol, 2001,75: 2684-2691.
  • 5Fernandez M, Quiroga JA, Carreno V. Hepatitis B virus downregulates the human interferon-inducible MxA promoter through direct interaction of precore/core proteins. J Gen Virol, 2003, 84(Pt 8): 2073-2082.
  • 6Femandez-Arcas N, Blanco A, Gaitan MI, et al. Differential transcriptional expresion of the polymorphic myxovirus resistance protein A in response to interferon-alpha treatment. Pharmacogenetics, 2004, 14:189-193.
  • 7King JK, Yeh SH, Lin MW, et al. Genetic polymorphisms in interferon pathway and response to interferon treatment in hepatitis B patients: Apilot study. Hepatology, 2002, 36: 1416-1424.
  • 8Peng XM, Gu L, Huang YS, et al. Simultaneous detection of two major lamivudine-resistant mutants using competitively differentiated-PCR. J Virol Methods, 2005, 128: 168-175.
  • 9Hamano E, Hijikata M, Itoyama S, et al. Polymorphisms of intvfferon-inducible genes OAS-1 and MxA associated with SARS in the Vietnamese population. Biochem Biophys Res Commun, 2005, 329: 1234-1239.
  • 10Torisu H, Kusuhara K, Kira R, et al. Functional MxA promoter polymorphism associated with subacute sclerosing panencephalitis. Neurology,2004, 62: 457-460.

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  • 1陈蕾,江国托,常维山.鸡MxA基因的克隆、表达及生物学活性检测[J].中国免疫学杂志,2006,22(11):1018-1020. 被引量:9
  • 2陈兵,罗欣,鲁云霞,徐从贞,张胜权.人白细胞介素29在cos-7细胞中表达及其体外抗乙型肝炎病毒作用[J].中国免疫学杂志,2007,23(5):411-414. 被引量:2
  • 3Lindenmann J,Lane C A,Hobson D. The resistance of A2G mice to orthomyxoviruses[J].J Immunol,1963,90:942-951.
  • 4Arnheiter H,Skuntz S,Notebom M,et al. Transgenic mice with intracellular immunity to influenza virus [J]. Cell,1990,62: 51-61.
  • 5Garber E A. Avian cells expressing the murine protein are resistant to influenza infection[J]. Virology, 1991,180:754-762.
  • 6Ko J H,Jin H K,Asano A,et al. Polymorphisms and the differential antiviral activity of the chicken Mx gene [J].J Genome Res ,2002,12(4) :595-601.
  • 7Kotenko S V, Gallagher G, Baurin V V, et al. IFNλs mediate antiviral protection through a distinct class Ⅱ cytokine receptor complex [ J ]. Nature Immunology ,2003,4 ( 1 ) :69 - 78.
  • 8Sheppard P, Kindsvogel W, Xu W, et al. IL-28,IL-29and their class Ⅱ cytokine receptor IL-28R[ J]. Nature Immunology,2003, 4(1): 63-8.
  • 9萨母布鲁斯J,弗里奇E F,曼尼阿蒂斯T.分子克隆实验指南[M].2版.北京:科学出版社,1996:876-87.
  • 10Bartlett N W, Dumoutier L, Renaukd J C, et al. A new member of the interleukin 10-related cytokine family encoded by a poxvirus [ J]. J Gen Virol,2004,85 : 1401 - 12.

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