药用氨基酸的应用及其生物催化与生物转化法生产

Applications,biocatalytic synthesis and biotransformation of pharmaceutical amino acids

目的对药用氨基酸的应用及其生物催化与生物转化法生产进展进行综述。方法查阅10余年来有关药用氨基酸的应用及其生物催化与生物转化法生产研究的国内外文献。结果药用氨基酸在疾病治疗和药物合成方面的应用广泛,生物催化和生物转化在药用氨基酸的生产中起的作用越来越重要。结论应加强生物催化和生物转化法制备药用氨基酸的研究。

OBJECTIVE To review the development of the applications,biocatalytic synthesis and biotransformation of pharmaceutical amino acids.METHOD To retrospect the domestic and foreign literature about the research on the applications,biocatalytic synthesis and biotransformation of pharmaceutical amino acids in the past 10 years.RESULTS Pharmaceutical amino acids are widely applied in disease treatment and pharmaceutical synthesis.Biocatalysis and biotransformation plays an increasingly important role in the production of pharmaceutical amino acids.CONCLUSION The research on biocatalytic synthesis and biotransformation of pharmaceutical amino acids should be strengthened.