高浓度澄明氯霉素泼尼松龙微乳滴眼液的药剂学实验研究

Pharmaceutical experiment studies for clarifing highly density chloramphenicol prednisolone microemulsion

目的解决氯霉素泼尼松龙滴眼液(俗称:氯强龙眼药水)中氯霉素有效浓度较低,泼尼松龙微粒混悬易沉降问题。方法 通过微乳化技术达到制备高浓度澄明氯强龙眼用新剂型。结果氯霉素泼尼松龙微乳滴眼液提高了氯霉素有效浓度,达1%,溶液澄清透明,热力学稳定性好,pH值适中,对眼刺激性小。结论氯霉素泼尼松龙微乳滴眼液是一种符合眼用制剂标准,质量优良,性质稳定的眼科用药新剂型。

OBJECTIVE To solve the problem that effective density in chloramphenicol among chloramphenicol prednisolone is lower and,the mixture and float in corpuscle easily sinks.METHODS Preparation for clarifying high density chloramphenicol prednisolone microemulsi on new dosage for eyes usage through/with high microemulsion technology.RESULTS Chloramphenicol prednisolone microemulsion has improved the effective density of chloramphenicol,to 1%,the liquid is clear and limpid with good thermodynamic stability,medium PH and less stimu lation for eyes.CONCLUSION Chloramphenicol prednisolone microemulsi on is a new dosage with good gualification and stable quantity which accords with criterion of medicine for eyes usage.