在乙醇中用电位滴定法测定依达拉奉原料药含量

Determination of edaravone bulk materia by potentiometric titration

目的建立依达拉奉原料药含量测定的容量分析方法。方法采用中性乙醇作溶剂,氢氧化钠标准滴定溶液作滴定剂,电位法指示终点的酸碱滴定法。结果用中性乙醇作溶剂的酸碱滴定法解决了依达拉奉在水中溶解度较小的问题。结论 该法操作简便,测定结果的精密度和准确度较好,适用于依达拉奉原料药的含量测定。

OBJECTIVE A method for the determination of edaravone bulk material was established.METHOD The acid-base titration was used,with the solvent of ethanol and the titrating solution of sodium hydroxide standard solution.RESULTS Solved the problem of edaravone solubility in the water by using ethanol as solvent.CONCLUSION The potentiometric titration is accurate and simple.It is suitable for the determination of edaravone bulk material.