摘要
目的 探讨药物自我治疗技能训练 (SelfMedicationManagementSkillTraining)对慢性精神分裂症的效果。方法 将 6 8例服用氯氮平治疗的慢性精神分裂症患者随机分为药物自我治疗技能训练组 (简称训练组 )和对照组。训练组患者进行技能训练 ,共 12周。采用临床大体印象量表 (CGI)、简明精神病评定量表 (BPRS)和阴性症状评定量表 (SANS)进行效果评定 ,同时检测氯氮平和去甲氯氮平血浓度、外周血T细胞亚群与白介素Ⅱ受体 (SIL 2R)。结果 训练组患者阴性症状的改善以及免疫因子CD3 + 、CD4+ 和CD4+ /CD8+ 的增高均优于对照组 (P <0 0 5 ) ,且药物自我治疗技能显著提高 (P <0 0 1)。
Objectives: This study was to explore the effects of Self Medication Management Skill Training on the treatment of chronic schizophrenic patients. Method: 68 chronic schizophrenic patients who were treated with clozapine were randomly assigned to medication management training group and control group. The training group patients took part in the training program for 12 weeks. CGI, BPRS and SANS were used to evaluate clinical improvement. Blood concentration of clozapine, T Cell subgroup and SIL 2R were monitored. Results: Negative symptoms and immune indicator CD 3+ 、CD 4+ 、CD 4+ /CD 8+ of the training group patients were improved significantly compared with that of control group ( P< 0 05). Knowledge and skills of medication management were also obtained by these patients ( P <0 01). Conclusion: Self Medication Management Skill Training had positive effects on the treatment and rehabilitation of chronic schizophrenic patients.
出处
《上海精神医学》
北大核心
2003年第2期83-86,共4页
Shanghai Archives of Psychiatry
关键词
慢性精神分裂症
药物自我治疗技能训练
Chronic schizophrenia Self medication management skill training
