96例精神药物过量患者资料分析

Analysis of chinical data of 96 patients with overdose of psychotropics

目的 分析服用过量精神病药物患者的临床相关资料及血药浓度。方法 回顾 1992～2 0 0 0年在上海市精神卫生中心就诊的精神药物过量的精神病患者的临床资料 ,分析疾病诊断、中毒药物的种类及血药浓度等。结果 共分析了 96例精神药物过量患者 ,诊断主要为精神分裂症 (6 5例 )及抑郁症 (2 3例 )。过量精神药物主要为氯丙嗪 (38例 )、氯氮平 (33例 )及苯二氮 卓艹 类 (2 1例 )。氯丙嗪血药浓度为 (1380 4± 1731 5 )ng/ml,氯氮平血药浓度为 (16 80 3± 2 337 4 )ng/ml。 结论 精神病患者中精神药物中毒以精神分裂症患者为主 ,其次为抑郁症患者。过量药物为常用的抗精神病药物氯丙嗪、氯氮平及苯二氮 卓艹 类。过量服药的患者的血药浓度较高 ,平均血药浓度明显高于治疗浓度。

Objective: To analyze the related clinical data and drug plasma concentration in patients with overdose of psychotropics. Methods: To retrospect the data of overdose patients in Shanghai Mental Health Center from 1992 to 2000 and analyze the diagnosis, sorts and drug plasma concentration. Results: Ninety six overdose patients were enrolled. Most of the patients were suffered with schizophrenia (65 case) and depression (23 case). Chlorpromazine (38 case), clozapine (33 case) and benzodiazepine (21 case) were the most common psychotropics overdosed in psychotic patients. The plasma drug concentrations of these drugs were higher than those with treatment dose. Conclusion: Schizophrenia and depression are the most common diseases in the patients of overdose. Antipsychotics and benzodiazepine are overdosed mostly. We should pay more attention to the patients who take these drugs and enhance the management of psychotropics.