强迫症与儿茶酚-邻-甲基转移酶基因多态性的关联分析

An analysis of association between polymorphism of catechol-O-methltransferase gene and obsessive-compulsive disorder

目的 探索上海地区汉族人口中儿茶酚 邻 甲基转移酶 (COMT)基因多态同强迫症的关系。方法 采用聚合酶链反应扩增技术与限制性片段长度多态 (PCR RFLP)测定 10 0例强迫症 (OCD)患者和 115例健康对照的基因型。结果 强迫症患者COMT基因型与等位基因分布与健康对照之间显著差异 (P >0 0 5 ) ;OCD患者与健康对照同性别之间COMT基因型与等位基因分布也未见显著差异(P >0 0 5 )。

Objective: To explore the relation between polymorphism of catechol O methyltransferas (COMT) gene and obsessive compulsive disorder (OCD) in the Han nationality of Shanghai. Methods: 100 OCD patients and 115 health controls were included in this study. All subjects were genotyped with the polymerase chain reaction and restriction fragment length polymorphism techniques (PCR RFLP). Results: There were no significant difference of genotype or allele frequencies of COMT gene between patients and controls or betweer patients and controls with the same gender. Conclusion: The results suggested that the polymorphism of COMT gene does not show genetic association with OCD incidence in the Han nationality.