摘要
目的 探索上海地区汉族人口中儿茶酚 邻 甲基转移酶 (COMT)基因多态同强迫症的关系。方法 采用聚合酶链反应扩增技术与限制性片段长度多态 (PCR RFLP)测定 10 0例强迫症 (OCD)患者和 115例健康对照的基因型。结果 强迫症患者COMT基因型与等位基因分布与健康对照之间显著差异 (P >0 0 5 ) ;OCD患者与健康对照同性别之间COMT基因型与等位基因分布也未见显著差异(P >0 0 5 )。
Objective: To explore the relation between polymorphism of catechol O methyltransferas (COMT) gene and obsessive compulsive disorder (OCD) in the Han nationality of Shanghai. Methods: 100 OCD patients and 115 health controls were included in this study. All subjects were genotyped with the polymerase chain reaction and restriction fragment length polymorphism techniques (PCR RFLP). Results: There were no significant difference of genotype or allele frequencies of COMT gene between patients and controls or betweer patients and controls with the same gender. Conclusion: The results suggested that the polymorphism of COMT gene does not show genetic association with OCD incidence in the Han nationality.
出处
《上海精神医学》
北大核心
2003年第4期193-195,共3页
Shanghai Archives of Psychiatry
基金
上海市卫生系统百人计划资助项目号 97BR0 3 0
关键词
强迫症
儿茶酚-邻-甲基转移酶
多态性
限制性片段长度
Obessive compulsive disorder Catechol O methyltransferas Polymorphism Restriction fragment length