消化性溃疡患者危险因素的初步对照研究

A primary controlled study of risk factors in patients with peptic ulcer

目的 探讨影响消化性溃疡患者的危险因素。方法 对31例消化性溃疡和34例慢性胃炎患者予症状自评量表(SCL-90)和生活事件量表(LES)评定,同时测血清胃泌素及血清一氧化氮进行对照分析。结果 (1)消化性溃疡患者SCL-90的躯体化、人际关系敏感、焦虑、抑郁、强迫分值较慢性胃炎组显著增高;(2)LES的工作问题分消化性溃疡组显著性高于对照组;(3)试验组血清胃泌素显著高于对照组,而血清一氧化氮则显著低于对照组。结论 对消化性溃疡患者应采取生物-心理-社会整体医学模式进行综合治疗。

Objective: To explore the influence of risk factors to the patients with peptic ulcer. Methods: Thirty-one patients with peptic ulcer and thirty-four patients with chronic gastricism were investigated by Symptom Checklist 90 (SCL-90) and Life Events Scale ( LES). Gastrin cortisone and nitrogen oxide in serum were measured. Results: The scores of some factors of SCL-90 and total scores, job problems factor scores of LES in patients with peptic ulcer were significantly higher than that in patients with chronic gastricism. Higher gastrin and less nitric oxide concentration in serum are found in test group than in control group. Conclusion? To treat the patients with peptic ulcer, bio-psycho-social factors should be systematically considered.