双黄连粉针剂的药代动力学研究

Study on pharmacokinetics of Shuanghuanglian injection powder

目的 研究双黄连粉针剂的主要有效成分黄芩甙的药代动力学 方法 实验采用反相高效液相法,对静脉注射双黄连粉针剂的家兔血药浓度进行检测,对所得数据用3P87程序进行分析 结果 家兔体内Baicalin的血药浓度随时间的变化符合开放式二室模型,其相应的各药动学参数为A:0 30207mg mL、α:12 35416h-1、B:0 17996mg mL、β:1 87489h-1、t1 2α:0 05611h、t1 2β:0 3697h 结论 黄芩甙在家兔体内为快速分布。

Objective To study and describe pharmacokinetics process of Baicalin the main effective ingredient of SHL injection powder Methods RHPLC was used to examine the administrated blood concentration of rabbit which intravenous injected SHL injection powder The data was analyzed by 3P87 Results The blood concentration of Baicalin in rabbit is accordance with two-compartment open model and its pharmacokinetics reference data is: A: 0302 07 mg/mL, α:12354 16 h-1,B:0179 96 mg/mL,β:1874 89 h-1,t1/2α:0056 11 h,t1/2β:0369 7 h Conclusion The Baicalin in the body of rabbit is a process of rapid dispatching and relieving