肾脏疾病血清尿液唾液酸含量的测定及其临床意义

Determination and Clinic Value of Sialic Acid in Nephropathy Patients

目的 了解肾脏病患者血 ,尿唾液酸的变化。方法 测定 42例肾病患者与 5 5例健康对照者的血清唾液酸(SSA) ,尿液唾液酸 (USA) ,总蛋白 (TP) ,总胆固醇 (TC) ,尿素氮 (BUN)及肌酐 (Cr)。结果 肾病组SSA ,USA ,TC ,BUN及Cr水平明显高于对照组 (P <0 .0 1) ,TP水平明显低于对照组 (P <0 .0 1)。结论 SSA、USA升高与肾脏损害程度有关 ,对肾脏病的诊断及判定有一定意义。

Objective To observe the changes of sialic acid in patients with nephropathy Method The serum sialic acid(SSA), urine sialic acid(USA), total protein(TP), total cholesterol(TC), blood wrine nitrogen(BUN)and creatinine(Cr)were determined in 42 cases of nephropathy patients and 55 cases of heatthy people respectively Result in nephropathy group, SSA, USA, TC, BUN and Cr were significantly higher than these in heacthy group( P <0.01)meanuhile, the TP was lower than the heactly groops'( P <0.01) Conclusion The in crease of SSA and USA is correlated to the degree of kindney damage, which has some value on the diagnosis and prognosis in nephropathy