直肠癌组织中血管内皮生长因子表达的研究

Study of Vascular Endothelial Growth Factor Expression in Rectum Cancer

目的 研究血管内皮长生因子 (VEGF)与直肠癌转移的关系。方法 应用流式细胞仪技术检测 5 6例直肠癌组织中VEGF的表达情况 ,并用免疫组织化学方法 ,通过Ⅷ因子的多克隆抗体检测微血管密度 (MVD)。结果 VEGF在直肠癌中高表达 ,阳性率为 76 8% ,VEGF的表达与MVD两者明显相关 ,且与直肠癌的淋巴结转移相关。结论 VEGF在直肠癌的转移中起重要作用。

Objective To study the expression of vascular endothelial growth factor(VEGF)and the relatonship between it and intratumoral microvessel density(MVD)and metastasis of rectum cancer Method By using flow cytometry, we detected the expression of VEGF in 56 case of rectum cancer; Intratumoral MVD was detected by factor Ⅷ polclonal antibody using immunohistochemistry Result VEGF expression was high in rectum cancer, the positive ratio was 76.8%; VEGF was closely related to MVD, and was significantly related to lymph node metastasis Conclusion VEGF played an important role in the metastasis of rectum cancer