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MTHFR C677T基因型、烟酒嗜好及其相互作用与胃癌 被引量：2

MTHFR C677T Geaotypes, Lifestyle and the Risk of Stomach Cancer
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摘要 目的:研究亚甲基四氢叶酸还原酶(MTHFR)基因C677T多态性及其和烟酒茶嗜好相互作用与胃癌易感性的关系.方法:在上消化道癌高发区淮安市进行了一个病例-对照研究(胃癌107例,人群对照200例),调查研究对象的生活习惯,采用PCR-RFLP技术检测研究对象的MTHFR基因型.结果:①胃癌组中MTHFR变异型等位基因携带者的比例为79.4%,显著高于对照组的68.5%(x2=4.15,P=0.0416).MTHFR变异型等位基因携带者发生胃癌的危险性显著升高(OR=1.78,95%CI:0.99～3.22;性别、年龄吸烟和饮酒习惯调整OR=1.79,95%CI:1.01～3.19).②与携带MTHFR野生基因型的不吸烟者相比,携带变异型基因且伴有吸烟习惯者发生胃癌的OR为7.82(95%CI:2.43～25.19),伴有经常饮酒的习惯者发生胃癌的OR为2.87(95%CI:1.28～6.47).与不吸烟、不经常饮酒的野生型MTHFR基因携带者相比,伴有吸烟和经常饮酒习惯的变异型基因携带者发生胃癌的OR为8.67(95%CI:2.12～40.94).结论:MTHFRC677T变异型基因型与胃癌的易感性有关;吸烟和饮酒与MTHFR变异基因型在胃癌发生中有明显的协同作用.调查生活习惯同时检测MTHFR基因型有助于胃癌高危人群和个体的筛选.
作者 高长明 吴建中 丁建华 刘燕婷 臧宇 李苏平 苏平 胡旭 徐天亮 TakeZaki Toshiro Tajima KaZuo
机构地区 江苏省肿瘤防治研究所流行病研究室 淮安市卫生防疫站 日本爱知县ガセタ一研究所疫学预防部日本爱知县ガセタ一研究所疫学预防部
出处 《中华肿瘤防治杂志》 CAS 2001年第z1期187-190,共4页 Chinese Journal of Cancer Prevention and Treatment
关键词 亚甲基四氢叶酸还原酶基因 C677T 吸烟 饮酒 胃癌
分类号 R735.2 [医药卫生—肿瘤] R73-31(253) [医药卫生—肿瘤]
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参考文献10

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同被引文献25

  • 1司佩任,房殿春,张浩,杨柳芹,罗元辉,廖化禹.胃癌亚甲基四氢叶酸还原酶基因多态性及其与微卫星不稳的关系[J].中华流行病学杂志,2005,26(10):794-799. 被引量：7
  • 2翁玉蓉,房静远,孙丹凤,陈朝飞,朱红音.胃癌组织中叶酸水平与代谢酶亚甲基四氢叶酸还原酶基因多态性的关系研究[J].中华消化杂志,2006,26(1):26-30. 被引量：8
  • 3KatherineDCrew,AlfredINeugut.Epidemiology of gastric cancer[J].World Journal of Gastroenterology,2006,12(3):354-362. 被引量：190
  • 4李松,祭美菊,侯鹏,何农跃.亚甲基四氢叶酸还原酶基因C677T和A1298C多态与胃癌的遗传易感性[J].东南大学学报（医学版）,2006,25(5):321-324. 被引量：6
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中华肿瘤防治杂志
2001年 第z1期

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