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GABAA受体失敏的研究进展

Progress in the Study of Desensitization of GABAA Receptors
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摘要 GABAA受体属于配体门控性离子通道超家族成员之一。当持续施加激动剂时,GABAA受体进入失敏状态,并且许多因素参与调节GABAA受体的失敏,如受体亚基构成、配体与受体的亲合力、磷酸化作用、膜电压的变化等都会影响受体的失敏过程。进入失敏状态的GABAA受体并非处于无功能状态,它们在调节抑制性突触后电流(IPSC)和快速抑制性突触传递中起到关键作用,并且可能参与调节突触的可塑性等过程。 The γ-aminobutyrie acid type A(GABAA) receptor is a member of the ligand-gated ion channel superfamily.Chronic γ-aminobutyrie acid(GABA) administration could desensitize GABAA receptors.Many factors which modulate the desensitization have been described,including composition of subunits,the affinity of ligand and receptor,phosphorylation,current potential of membrane,and so on.The desensitization of GABAA receptors plays a crucial role in modulating inhibitory postsynaptic currents(IPSC) and has a great imp...
作者 王仁俊 曾庆华
机构地区 吉林师范大学生命科学学院 东北师范大学
出处 《白城师范学院学报》 2007年第3期43-45,73,共4页 Journal of Baicheng Normal University
关键词 失敏 GABAA受体 Γ-氨基丁酸 可塑性 desensitization GABAA receptors GABA plasticity
分类号 Q42 [生物学—神经生物学]
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  • 1鲁涛,杨雄里.鲫鱼视网膜水平细胞的分离、形态及生理特性[J].神经解剖学杂志,1995,11(4):299-306. 被引量：4
  • 2[1]Klein RL, Harris RA. Regulation of GABAA receptor structure and function by chronic drug treatments in vivo and with stably transfected cells. Jpn J Phmacol, 1996,70(1) :1 - 15.
  • 3[2]Suzuki T, Mizoguchi H, Noguchi H, et al. Effects of flunarizine and diltiazem on physical dependence on barbital in rats. Pharmacol Biochem Behave, 1993,45(3) :703 - 712.
  • 4[3]Kumamoto E. The pharmacology of amino-acid responses in septal neurons. Prog Neurobiology, 1997,52(3): 197 - 259.
  • 5[4]Wilke K, Gaul R, Klauk SM, et al. Gene in human chromosome band Xq28 (GABRE) defines a putative new subunit class of the BABAA neurotransmitter receptor. Genomics, 1997,45(1): 1 - 10.
  • 6[5]McKeman RM, Whiting PJ. Which GABAA-receptor subtypes really occur in the brain? Trends Neurosci, 1996, 19(4): 139 - 143.
  • 7[6]Frischy JM, Mohler H. GABAA-receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J Comp Neurol, 1995,359( 1 ): 154- 194.
  • 8[7]Fritschy JM, Benke D, Johnson DK, et al. GABAA-receptor alphasubunit is an essential prerequisite for receptor formation in vivo.Neuroscience, 1997,81(4): 1043 - 1053.
  • 9[8]Holt RA, Bateson AN, Martin IL. Chronic treatment with diazepam or abecarnil differently affects the expression of GABAA receptor subunit mRNAs in the rat cortex. Neuropharmacology, 1996,35(9- 10): 1457 - 1463.
  • 10[9]Sieghart W. Structure and pharmacology of gamma-aminobutyric acidA receptor subtypes. Pharmacol Rev, 1995,47(2): 182 - 234.

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白城师范学院学报
2007年 第3期

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