摘要
目的探讨血清白细胞介素18(IL-18)、白细胞介素10(IL-10)水平在2-型糖尿病发病机制中的作用;方法42例2-型糖尿病患者和一般临床资料相匹配的40例健康志愿者,采用酶联免疫吸附法(ELISA)测定血清IL-18、IL-10水平,全自动生化分析仪测定空腹血糖、甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)及低密度脂蛋白胆固醇(LDL-C)。对照观察两组间各指标差异,用Pearson相关分析探讨血清IL-18、IL-10水平与各临床指标的相关性;结果2-型糖尿病组血清IL-18水平、IL-18/IL-10比值均较对照组增高,两者比较有显著性差异(P<0.05),而血清IL-10水平两组间比较差异无显著性。血清IL-18与空腹血糖、TG、HDL-C显著相关(P<0.05),Pearson相关系数(r值)分别为0.47、0.52、-0.43,而血清IL-10与各临床指标均无相关性;结论血清IL-18水平增高可能是2-型糖尿病的关键致病因素,而血清IL-10水平与2-型糖尿病发病关系不大。
Objective To investigate the effect of IL-18,IL-10 on pathogeny of type 2 Diabetes patients.Methods 42 cases of type 2 Diabetes and matched 40 cases of healthy volunteer were included.The serum IL-18 and IL-10 levels were detected by ELISA.The contents of fasting blood-glucose,TG,TC,HDL-C and LDL-C were analyzed by automitic biochemical analyzer.The data of the two groups were compared,and pearson’s correlation analysis was used to investigate the relationship between serum IL-18 or IL-10 level and all clinical datas.Results the serum IL-18 level,and ratio of IL-18/IL-10 of type 2 Diabetes group were higher than the control group,there were observious difference(P<0.05).There were no difference of the serum lever of IL-10 between the two groups;The serum IL-18 level showed a significant correlation with fasting blood-glucose,TG and HDL-C(r=0.47,0.52 and-0.43,P<0.05).There were no correlation between IL-10 and all of clinical datas.Conclusion the increaded serum IL-18 level maybe the key pathogenesis factor of type 2 Diabetes,and there was no relationship between IL-10 and type 2 Diabetes.
出处
《医学检验与临床》
2008年第2期53-55,共3页
Medical Laboratory Science and Clinics
