Ⅱ型糖尿病患者ET、IL-6、TNF的变化

The change research of ET,IL-6 and TNF in patients with type 2 diabetes mellitus

目的探讨Ⅱ型糖尿病患者血浆内皮素(ET)、白介素-6(IL-6)、肿瘤坏死因子(TNF-a)在糖尿病发生、发展过程中的变化。方法用放射免疫分析法检测84例Ⅱ型糖尿病患者及42例健康体检者ET、IL-6、TNF-a水平。结果Ⅱ型糖尿病患者血浆ET、IL-6、TNF-a明显高于正常对照组(p<0.01),有合并症患者ET、TNF-a明显高于单纯糖尿病患者(P<0.05);三种细胞因子间浓度呈正相关(p<0.01)。结论ET、IL-6、TNF-a在糖尿病的发生、发展过程中相互作用,观察其浓度变化对探讨糖尿病的发病机理、预防及指导用药均有重要价值。

Objective To research the changed rule of endothelin-1(ET-1), interleukin-6(1L-6) and tumor necrosis factor alpha(TNFα) through the occurrence and development of diabetes mellitus(DM).Methods The blood levels of ET,IL-6 and TNFα are detected by radio immunoassay for 84 patients with 2-DM and 42 healthy adults.Results The levels of ET,IL-6 and TNFα in blood plasma of patients with 2-DM areobviously higher than that in normal control group(P<0.01),the levels of ET and TNFα in blood plasma in patients with diabetic complications are higher than that in the patients with pure DM(P<0.05),and they have direct relationship(P<0.01).Conclusion ET,IL-6 and TNFα are interacted through the occurrence and development of DM,so the research of them is very important to study the etiopathogenesis,to prevent disease and to guide medication.