联合检测ADA、LDH和CRP对结核性与恶性胸腔积液的诊断价值

The diagnosis value of adenosine daminase,C-reactive protein and lactate dehydrgenase combined detection for tuberculosis and malignat plural effusion

目的探讨联合测定胸腔积液中的腺苷脱氨酶(ADA)、乳酸脱氢酶(LDH)和C反应蛋白(CRP)在结核性与恶性胸腔积液上鉴别诊断的价值。方法酶法和免疫比浊法检测59例结核性胸腔积液和17例恶性肿瘤积液中ADA、LDH和CRP的含量,并进行统计学分析。结果结核性胸腔积液中ADA和CRP水平显著高于恶性积液的值,具有统计学意义,P<0.01。但是,结核性胸腔积液中LDH含量低于恶性积液的LDH值,有显著性差异,P<0.01。结论胸腔积液中ADA、LDH和CRP的联合检测,对鉴别结核性与恶性胸腔积液有重要价值。

Objective To explore the values on the adenosine deaminase(ADA) C-reactive protein(CRP) and lactate dehydrogenase(LDH) measurements for the differentiation between tuberculosis and malignant plural effusion.Methods Adenosine deaminase and lactase dehydrogenase were detected by enzymetic method,while C-reactive protein by immunological method.Results The levels of ADA,CRP in tuberculous pleural fluids were higher than those in malignant pleural effusions,and there were significant differences(p<0.01).But the levels of lactate dehydrogenase in malignant effusions were significantly higher than those in tuberculous pleural fluids.Conclusions Our results showed that combined determinations of ADA,LDH and CRP in pleural fluid was helpful in the differentiation between tuberculous pleural fluids and malignant pleural effusions.