S-100B蛋白测定在早产儿缺氧缺血性脑病早期诊断的意义

Significance of S-100 measurement in early diagnosis for premature infant with hypoxic-ischemic encephalopathy

目的通过测定早产儿缺氧缺血性脑病(HIE)患儿血清S-100B蛋白含量的变化,研究其在早产儿HIE早期诊断及预后的意义。方法选择临床诊断为HIE的早产儿78例为观察组,其他早产儿40例为对照组,采用酶联免疫吸附试验、双抗体夹心法检测二组血清S-100B蛋白含量,进行比较研究。结果观察组含量明显高于对照组,差异有显著性,血清S-100B蛋白含量与早产儿脑损伤程度呈正相关。结论早期检测早产儿血清S-100B蛋白含量对早产儿HIE早期诊断有重要价值,优于脑CT检查。

Objective:To study the significance for the early diagnosis and prognosis with premature infant with hypoxic-ischemic encephalopathy by measure the serum S-100B protein。Methods:S-100B protein was measured dynamically by ELASA in blood serum from 78 patients with HIE,40 references. The patients were divided into two groups according to the severity of disease:the mild group,the medium-severe group. Results:The level of blood serum S-100B protein in HIE group was higher than that of the control group (P<0.01)and the variety is associated with the severity of disease. Conclusion:Early measure of the content of serum S-100B protein of the premature infants with hypoxic-ischemic encephalopathy had significant value to the early diagnosis of HIE.