苯那普利联合霉酚酸酯治疗早期糖尿病肾病的疗效观察

Study on Therapeutic Effect of Benazpril Combined with MMF on Early Diabetic nephropathy

目的:探讨苯那普利联合霉酚酸酯(MMF)治疗早期糖尿病肾病(DN)的临床疗效。方法:30例早期Ⅱ型糖尿病肾病(DN)患者,随机分为治疗组和对照组,治疗组使用苯那普利、霉酚酸酯(MMF)联用,对照组单用苯那普利,疗程12周。观察两组患者治疗前后的平均动脉压(MAP)、尿白蛋白排泄率(UAER)、内生肌酐清除率(Ccr)、血清肌酐(SCr)、空腹血糖(FBG)、糖化血红蛋白(HbA1C)、血脂等变化。结果:治疗组与观察组对早期DN均有明显降低血压、UAER、SCr的作用,各组在治疗前后差异具有明显统计学意义(P<0.01或P<0.05),但治疗组效果更好,尤其降低UAER作用有明显差异(P<0.01),各组间FBG、CH、TG治疗前及治疗后比较无统计学意义。结论:苯那普利联合MMF治疗早期DN有确切疗效。

Objective To observe the therapeutic effect of Benazpril combined with MMF on diabetic nephropathy.Methods The treatment group was treated with Benazpril combined with MMF,while the observation group with benazpril alone;Both groups were observed for determination of MAP,UAER,CCr,SCr,FBG and HbA1C,etc.before initiation of therapy and after treatment for 12 weeks.Results Significant decrease was detected in blood pressure,UAER and BUN(P<0.01 or P<0.05);the treatment group's decrease especially in UAER was mo...