摘要
目的:改进盐酸托烷司琼的合成工艺。方法:以吲哚-3-甲酸为起始原料,酰氯化后与托品醇锂发生缩合反应,再与盐酸成盐制得盐酸托烷司琼。结果:所得产品经元素分析、红外光谱及核磁共振氢谱等确证了结构,含量达到药用标准,总收率52.8%。结论:本工艺简化了缩合反应后处理过程,改进了产品的纯化条件,提高了产品质量,并适合工业化生产。
Objective To improve the synthesis of tropisetron hydrochlorride.Methods tropisetron hydrochloride was synthesized from indol-3-yl carboxylic acid by chlorination and condensation with tropic alcohol lithium,then salt formation with hydrochlororic acid.Results Chemical structure of tropisetron hydrochlorride was confirmed by element analysis,IR and 1HNMR etc,the overall yield was 52.8%.Cnnclusion The process was simplified,improved and practice in industrialize.
出处
《湖南师范大学学报（医学版）》
2006年第4期29-30,共2页
Journal of Hunan Normal University(Medical Sciences)
关键词
盐酸托烷司琼
合成
吲哚-3-甲酸
托品醇锂
Tropisetron hydrochloride
Synthesis
indol-3-yl carboxylic acid
tropic alcohol lithium
