氮芥联合低分子肝素治疗难治性肾病综合征临床疗效分析

Effect Of Chloromethine Combined with Low Moleculer Weight Heparin on Refractory Nephrotic Syndrome

目的:观察氮芥联合低分子肝素(LMWH)治疗难治性肾病综合征的疗效。方法:32例难治性肾病综合征患者予盐酸氮芥静脉注射,由1 mg开始,隔日注射一次,每次加量1 mg,至5 mg后每周注射2次,累积量达1.5-2.0 mg/kg体重(约80-100 mg)后停药;联合低分子肝素5000 u皮下注射,一日两次。结果:总有效率85.7%,治疗期间无严重不良反应,治疗前后尿量、尿蛋白、血浆白蛋白、总胆固醇、甘油三脂均有显著变化(P<0.05)。伴肾功能不全者肾功能均恢复正常。结论:氮芥联合低分子肝素治疗难治性肾病综合征安全有效。

Objective To observe the effect of chloromethine combined with LMW on refractory nephrotic syndrome(NS).Methods 32 patients with refractory NS were given chlormethine injected once per two days from 1mg to 5mg(1 mg injection was added every time).When the dose added to 5 mg,chlormethine was given twice per week.The treatment ended when the cumulant of chlormethine reached 1.5-2.0 mg/kg(about 80-100 mg).During the period of treatment,LMWH(5000IU) was given twice per day.Results It was found that 85.7% patien...