无创呼吸机治疗慢性阻塞性肺疾病合并严重Ⅱ型呼吸衰竭的临床研究

Clinical Study of Noninvasive Positive Pressure Ventilation in Severe Respiratory Failure of Chronic Obstructive Pulmonary Disease

目的:探讨鼻(面)罩无创正压通气(NIPPV)在慢性阻塞性肺疾病(COPD)合并严重Ⅱ型呼吸衰竭的治疗作用。方法:回顾性研究35例伴严重Ⅱ型呼吸衰竭(PaCO2>80mmHg)的COPD急性发作期患者,在常规治疗基础上给予NIPPV治疗,并监测血气分析、临床征象等情况。结果:NIPPV 3 h迅速改善了患者的血气(PH、PaO2、PaCO2、SaO2)(P<0.05),通气24 h至治疗72 h可获进一步改善(P<0.01)。治疗成功率达88.6%(31/35)。结论:N IPPV是治疗COPD合并严重Ⅱ型呼衰竭的有效手段。

Objective To investigate the clinic effect of the facemask noninvasive positive pressure ventilation(NIPPV) in acute exacerbations of chronic obstructive pulmonary disease(COPD).Methods 35cases of severe respiratory failure due to COPD(PaCO2 > 80 mm Hg) were prospectively investigated,Blood gas,clinic signs were monitored before,during and after continous NIPPV.Results Bloodgases(PH,PaO2,PaCO2,SaO2)were improved rapidly 3 h after treatment(P<0.05),and further improved 24 h,72 h after treament(P<0.01),clinic...